Comparative Genomics and Reverse Vaccinology of Streptococcus iniae: Blueprints for Affordable Aquaculture Vaccines

Abstract

The high cost of vaccines relative to antimicrobials in aquaculture limits their adoption, particularly in low-value freshwater fish that nonetheless play a crucial role in global food security. Current vaccines, killed or live attenuated are highly effective but are no longer cost-efficient. Here, we present a new framework that leverages epidemiology, pangenomics, and reverse vaccinology with Quality By Design (QbD) principles to design more affordable vaccines. Targeting a range of aquatic streptococcal species, we emphasize the fish pathogen Streptococcus iniae. We identify a subset of protein antigens from the proteome that are well-adapted for low-cost mass production using QbD manufacturing strategies. This integrated approach is a crucial step towards making vaccines more accessible and cost-effective for global aquaculture, ultimately aiding in combating antimicrobial resistance and ensuring food security and consumer health.

Quentin Andres

Second Year PhD Candidate in Fisheries Science and Technology (International Program)

Specializing in aquaculture, molecular biology, genomics, and bioinformatics.